The Toronto Blue Jays travel to Baltimore for a Wednesday night regular season clash against the Orioles at Oriole Park at Camden Yards, with first pitch set for 6:35 PM ET on September 23, 2026. No probable pitchers have been announced for either side, adding a layer of uncertainty to a matchup that carries genuine late-season weight. What we do know is this: Baltimore is rolling out a lineup anchored by Gunnar Henderson and Pete Alonso, while Toronto counters with Alejandro Kirk in the heart of the order and a supporting cast fighting for every win down the stretch.

Baltimore Orioles Lineup: Henderson and Alonso Headline a Dangerous Order

The Orioles are not messing around. Baltimore sends a formidable top of the order to the plate, with Dylan Beavers leading off in right field, Pete Alonso hitting second at first base, and Gunnar Henderson slotted third at shortstop. That is as much run-producing potential as you will find in a two-three hole in the American League. Coby Mayo bats cleanup at third base, with Christian Encarnacion-Strand occupying the DH spot at five. Colton Cowser, Jeremiah Jackson, Christian Franklin, and Yohel Pozo round out the bottom of the order. This is a lineup with genuine thump from top to bottom.

Toronto Blue Jays Lineup: Kirk, Okamoto, and Schneider Look to Generate Offence

Toronto's lineup has a different look to it Wednesday. Nathan Lukes opens things up in right field, with Josh Smith batting second at second base. Alejandro Kirk hits third behind the plate — a familiar and stabilizing presence for this offence. Kazuma Okamoto slots in as the designated hitter at cleanup, with Sean Keys at first base hitting fifth. Davis Schneider bats sixth in left field, followed by Charles McAdoo at third, Myles Straw in centre, and Ernie Clement closing the order at shortstop. It is a lineup that will need to manufacture runs and stay disciplined against whatever Baltimore puts on the mound.

Keys to Watch Wednesday Night

• Pitching reveal: With no probable starters announced for either club, the pitching picture is the biggest question mark heading into first pitch. Watch for lineup clues and warmup activity to emerge closer to game time.
• Kirk's production: Alejandro Kirk batting third is a sign Toronto needs production from the catcher's spot. His ability to put the ball in play and work counts will be critical against whatever Baltimore throws out.
• Handling Henderson: Gunnar Henderson is the engine of Baltimore's offence. Keeping him off the bases and limiting big innings around the three-hole will be essential for the Jays to stay competitive.
• Schneider's bat: Davis Schneider has shown the ability to impact a game in a single swing. A hot moment from Schneider in the middle innings could swing momentum Toronto's way.
• Bottom-of-order productivity: Straw and Clement at the eight and nine spots need to set the table for Lukes and Smith. If Toronto's bottom third of the lineup goes quiet, the offence stalls quickly.

Prediction: Orioles Hold the Edge at Home

Without confirmed starters, projecting a winner comes with real limitations — pitching matchups move the needle more than any other single variable in baseball. That said, Baltimore's lineup carries a clear edge on paper Wednesday. Henderson and Alonso give the Orioles a high-end ceiling that Toronto's order, as currently constructed, will need to match through depth and situational hitting. If Kirk and Okamoto produce together in the middle of the Jays' lineup and Toronto's bullpen holds, this game stays close. But Camden Yards gives Baltimore a familiar advantage, and the Orioles' lineup depth makes them the favourite heading into the night. Expect a competitive game, with Baltimore edging Toronto by a run or two.

Catch all the action Wednesday at 6:35 PM ET on Sportsnet and SN590 THE FAN.